Excess serum Na level in rats administered with high doses of (−)-epigallocatechin gallate-casein nanoparticles prepared with sodium caseinate-Reference-Cited by-同舟云学术

Excess serum Na level in rats administered with high doses of (−)-epigallocatechin gallate-casein nanoparticles prepared with sodium caseinate

Published:2022 Issue:3 Volume:13 Page:1291-1298
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Zhang Yahui¹,Han Shuya¹,Wang Yin²,Zhang Haihua¹,Yu Chenhuan³,Qin Dingkui¹,Du Qizhen¹,Jin Peng¹^ORCID

Affiliation:

1. College of Food and Health Sciences, Zhejiang A & F University, Hangzhou 311300, China

2. Institute of Hygienics, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China

3. Experimental Animal Center, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China

Abstract

The 28-day oral toxicity test of 5.0 g per kg BW FD-EGCG-NPs on rats did not show any adverse effect. However, Na level in the serum of females and males treated with 10.0 g per kg BW FD-EGCG-NPs or FD-NPs significantly increased (P < 0.05).

Funder

Zhejiang A and F University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/FO/D1FO02890A

Reference33 articles.

1. Dual-drug loaded nanoparticles of Epigallocatechin-3-gallate (EGCG)/Ascorbic acid enhance therapeutic efficacy of EGCG in a APPswe/PS1dE9 Alzheimer's disease mice model

2. Microbiota facilitates the formation of the aminated metabolite of green tea polyphenol (-)-epigallocatechin-3-gallate which trap deleterious reactive endogenous metabolites

3. Potential Therapeutic Targets of Epigallocatechin Gallate (EGCG), the Most Abundant Catechin in Green Tea, and Its Role in the Therapy of Various Types of Cancer

4. Epigallocatechin-3-Gallate Is Absorbed but Extensively Glucuronidated Following Oral Administration to Mice

5. Nanoformulations to Enhance the Bioavailability and Physiological Functions of Polyphenols

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