The cycloaspeptides: uncovering a new model for methylated nonribosomal peptide biosynthesis-Reference-Cited by-同舟云学术

The cycloaspeptides: uncovering a new model for methylated nonribosomal peptide biosynthesis

Published:2018 Issue:17 Volume:9 Page:4109-4117
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

de Mattos-Shipley Kate M. J.¹²³⁴,Greco Claudio¹²³⁴^ORCID,Heard David M.¹²³⁴^ORCID,Hough Gemma⁵⁶⁴,Mulholland Nicholas P.⁵⁶⁴,Vincent Jason L.⁵⁶⁴,Micklefield Jason¹⁷⁸⁴^ORCID,Simpson Thomas J.¹²³⁴^ORCID,Willis Christine L.¹²³⁴^ORCID,Cox Russell J.⁹¹⁰¹¹¹²¹³^ORCID,Bailey Andrew M.¹⁴²³⁴^ORCID

Affiliation:

1. School of Chemistry

2. University of Bristol

3. Bristol

4. UK

5. Syngenta Ltd.

6. Jealott's Hill International Research Centre Bracknell

7. University of Manchester

8. Manchester

9. Institute für Organsche Chemie

10. Leibniz Universität Hannover

11. 30167 Hannover

12. Germany

13. BMWZ

14. School of Biological Sciences

Abstract

The cycloaspeptide gene cluster includes a pathway-specific N-methyl transferase. Its disruption allowed incorporation of N-methylated amino acids provided in the culture medium, allowing efficient production of cycloaspeptide E and novel related products.

Funder

Biotechnology and Biological Sciences Research Council

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/SC/C8SC00717A

Reference23 articles.

1. Studies on fungal products. XI Isolation and structures of novel cyclic pentapeptides from Aspergillus sp. NE-45.

2. Four psychrotolerant species with high chemical diversity consistently producing cycloaspeptide A, Penicillium jamesonlandense sp. nov., Penicillium ribium sp. nov., Penicillium soppii and Penicillium lanosum