Design and synthesis of novel chloropyridazine hybrids as promising anticancer agents acting by apoptosis induction and PARP-1 inhibition through a molecular hybridization strategy

Author:

Abdelrahman Norhan A.1,Al-Karmalawy Ahmed A.23ORCID,Jaballah Maiy Y.1,Yahya Galal45,Sharaky Marwa67,Abouzid Khaled A. M.1ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain-Shams University, Cairo 11566, Egypt

2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta 34518, Egypt

3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Giza 12566, Egypt

4. Department of Microbiology and Immunology, Zagazig University, Zagazig 44519, Egypt

5. Molecular Biology Institute of Barcelona, Spanish National Research Council, Catalonia, Spain

6. Cancer Biology Department, Pharmacology Unit, National Cancer Institute (NCI), Cairo University, Cairo, Egypt

7. Biochemistry Department, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Giza 12566, Egypt

Abstract

Novel chloropyridazine hybrids as promising anticancer agents acting by apoptosis induction and PARP-1 inhibition through a molecular hybridization strategy.

Publisher

Royal Society of Chemistry (RSC)

Reference62 articles.

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3. How Cancer Arises

4. M.Andreeff , D. W.Goodrich and A. B.Pardee , Proliferation, in Holland-Frei Cancer Medicine , ed. D. W. Kufe , R. E. Pollock and R. R. Weichselbaum , et al. , BC Decker , Hamilton, (ON) , 6th edn, 2003

5. M.Kozłowski and S.Tarlaci , Cancerous Tumor Life: Biological and Physical Aspects , SULTAN TARLACI , 2023

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