Dual-microRNA-controlled double-amplified cascaded logic DNA circuits for accurate discrimination of cell subtypes-Reference-Cited by-同舟云学术

Dual-microRNA-controlled double-amplified cascaded logic DNA circuits for accurate discrimination of cell subtypes

Published:2019 Issue:5 Volume:10 Page:1442-1449
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Quan Ke¹²³⁴⁵,Li Jing¹²³⁴⁵,Wang Jiaoli¹²³⁴⁵,Xie Nuli¹²³⁴⁵,Wei Qiaomei¹²³⁴⁵,Tang Jinlu¹²³⁴⁵,Yang Xiaohai¹²³⁴⁵^ORCID,Wang Kemin¹²³⁴⁵^ORCID,Huang Jin¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Chemo/Biosensing and Chemometrics

2. College of Chemistry and Chemical Engineering

3. Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province

4. Hunan University

5. Changsha

Abstract

We have designed dual-microRNA-controlled cascaded logic DNA circuits for cancer cell subtype identification. The basic idea is to improve sensitivity by cascading DNAzyme and hybridization chain reaction (HCR), and improve accuracy by simultaneous detection of miR-122 and miR-21.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Hunan Province

Hunan Provincial Innovation Foundation for Postgraduate

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C8SC04887H

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1. Array of hope: expression profiling identifies disease biomarkers and mechanism