Copper(i)/Ganphos catalysis: enantioselective synthesis of diverse spirooxindoles using iminoesters and alkyl substituted methyleneindolinones

Author:

Cui Hao12345,Li Ke12345,Wang Yue12345,Song Manman12345,Wang Congcong12345ORCID,Wei Donghui12345ORCID,Li Er-Qing12345ORCID,Duan Zheng12345ORCID,Mathey François12345ORCID

Affiliation:

1. College of Chemistry

2. Green Catalysis Center

3. International Phosphorus Laboratory

4. International Joint Research Laboratory for Functional Organophosphorus Materials of Henan Province

5. Zhengzhou University

Abstract

A copper/Ganphos-catalyzed asymmetric 1,3-dipolar cycloaddition of glycine iminoesters with alkyl substituted 3-methylene-2-oxindoles is described, producing the spiro[pyrrolidin-3,3′-oxindole]s in good yields with high ee.

Funder

National Natural Science Foundation of China

Ministry of Industry and Information Technology of the People's Republic of China

China Postdoctoral Science Foundation

Zhengzhou University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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