Diversification of polyketide structures via synthase engineering-Reference-Cited by-同舟云学术

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Diversification of polyketide structures via synthase engineering

Published:2019 Issue:8 Volume:10 Page:1256-1272
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Kornfuehrer Taylor¹²³⁴⁵,Eustáquio Alessandra S.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Medicinal Chemistry and Pharmacognosy and Center for Biomolecular Sciences

2. College of Pharmacy

3. University of Illinois at Chicago

4. Chicago

5. USA

Abstract

We present examples of polyketide structure diversification along with a perspective on the present and future of polyketide synthetic biology.

Funder

University of Illinois

National Center for Advancing Translational Sciences

National Center for Complementary and Integrative Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MD/C9MD00141G

Reference100 articles.

1. Natural Products as Sources of New Drugs from 1981 to 2014

2. History of antimicrobial drug discovery: Major classes and health impact

3. Developing natural product drugs: Supply problems and how they have been overcome

4. Challenges and discoveries in the total synthesis of complex polyketide natural products

5. Importance of microbial natural products and the need to revitalize their discovery

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