Iron-catalyzed [3 + 2 + 1] annulation of 2-aminobenzimidazoles/3-aminopyrazoles and aromatic alkynes using N,N-dimethylaminoethanol as a one carbon synthon for the synthesis of pyrimido[1,2-a]benzimidazoles and pyrimido[1,2-b]indazoles-Reference-Cited by-同舟云学术

Iron-catalyzed [3 + 2 + 1] annulation of 2-aminobenzimidazoles/3-aminopyrazoles and aromatic alkynes using N,N-dimethylaminoethanol as a one carbon synthon for the synthesis of pyrimido[1,2-a]benzimidazoles and pyrimido[1,2-b]indazoles

Published:2022 Issue:20 Volume:9 Page:5624-5630
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Qin Zemin¹²³,Zhang Ruiqin²,Ying Shenpeng¹,Ma Yongmin¹²^ORCID

Affiliation:

1. Taizhou Central Hospital (Taizhou University Hospital), Taizhou University, Jiaojiang, Zhejiang, 318000, P. R. China

2. Institute of Advanced Studies and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Zhejiang, 318000, P. R. China

3. School of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, 310053, P. R. China

Abstract

A simple and efficient method for the synthesis of pyrimido[1,2-a]benzimidazoles and pyrimido[1,2-b]indazoles by a three-component [3 + 2 + 1] annulation catalyzed by FeCl3 has been established.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QO/D2QO01008A

Reference61 articles.

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3. Iodine‐Catalyzed Double [4+2] Oxidative Annulations for the Synthesis of Bipyrazines from Ketones and Diamines by a Domino Strategy

4. A Synthetic Protocol for the Construction of Chroman‐Spiroquinazolin(thi)one Framework via a Metal‐Free, Three‐Component, Domino, Double Annulations

5. Palladium-Catalyzed [4+2] Annulation of Aryl and Alkenyl Carboxamides with 1,3-Dienes via C–H Functionalization: Synthesis of 3,4-Dihydroisoquinolones and 5,6-Dihydropyridinones

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