α-C–H difluoroalkylation of alkyl sulfoxides via intermolecular Pummerer reaction-Reference-Cited by-同舟云学术

α-C–H difluoroalkylation of alkyl sulfoxides via intermolecular Pummerer reaction

Published:2021 Issue:6 Volume:8 Page:1280-1287
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Huang Xin¹²³⁴,Zhao Weizhao¹²³⁴,Liang Yuchen⁵⁶⁷⁴,Wang Minghui¹²³⁴,Zhan Yaling¹²³⁴,Zhang Yage¹²³⁴,Kong Lichun¹²³⁴,Wang Zhi-Xiang⁵⁶⁷⁴^ORCID,Peng Bo¹²³⁴^ORCID

Affiliation:

1. Key Laboratory of the Ministry of Education for Advanced Catalysis Materials

2. Zhejiang Normal University

3. Jinhua 321004

4. China

5. School of Chemical Sciences

6. University of the Chinese Academy of Sciences

7. Beijing 100049

Abstract

A simple and practical intermolecular Pummerer reaction using difluoroenol silyl ethers as nucleophiles is described. The protocol allows for highly efficient α-difluoroalkylation of a wide spectrum of alkyl sulfoxides.

Funder

Natural Science Foundation of Zhejiang Province

National Natural Science Foundation of China

Zhejiang Normal University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/QO/D0QO01513J

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