A sensitive HPLC-FL method to simultaneously determine febuxostat and diclofenac in rat plasma: assessment of metabolic drug interactions in vitro and in vivo-Reference-Cited by-同舟云学术

A sensitive HPLC-FL method to simultaneously determine febuxostat and diclofenac in rat plasma: assessment of metabolic drug interactions in vitro and in vivo

Published:2020 Issue:16 Volume:12 Page:2166-2175
ISSN:1759-9660
Container-title:Analytical Methods
language:en
Short-container-title:Anal. Methods

Author:

Han Dong-Gyun¹²³⁴⁵,Kim Kyu-Sang⁶⁷⁸⁵,Seo Seong-Wook¹²³⁴⁵,Baek Young Mee⁹³⁴⁵,Jung Yunjin¹²³⁴⁵,Kim Dae-Duk⁶⁷⁸⁵,Yoon In-Soo¹²³⁴⁵^ORCID

Affiliation:

1. Department of Manufacturing Pharmacy

2. College of Pharmacy

3. Pusan National University

4. Busan

5. South Korea

6. College of Pharmacy and Research Institute of Pharmaceutical Sciences

7. Seoul National University

8. Seoul

9. Cultural Heritage Preservation Research Institute

Abstract

We developed a sensitive, simple and validated HPLC-FL method for simultaneous determination of FEB and DIC in rat plasma. The method requires a relatively small volume of sample, has simple sample preparation and excellent sensitivity.

Funder

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/AY/D0AY00471E

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