Conformational dynamics and self-association of intrinsically disordered Huntingtin exon 1 in cells-Reference-Cited by-同舟云学术

Conformational dynamics and self-association of intrinsically disordered Huntingtin exon 1 in cells

Published:2017 Issue:17 Volume:19 Page:10738-10747
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Büning Steffen¹²³⁴,Sharma Abhishek¹²³⁴,Vachharajani Shivang¹²³⁴,Newcombe Estella⁵⁶⁷⁸,Ormsby Angelique⁵⁶⁷⁸,Gao Mimi¹²³⁴,Gnutt David¹²³⁴,Vöpel Tobias¹²³⁴,Hatters Danny M.⁵⁶⁷⁸,Ebbinghaus Simon¹²³⁴^ORCID

Affiliation:

1. Department of Physical Chemistry II

2. Ruhr-University Bochum

3. D-44780 Bochum

4. Germany

5. Department of Biochemistry and Molecular Biology & Bio21 Molecular Science and Biotechnology Institute

6. University of Melbourne

7. Melbourne

8. Australia

Abstract

In-cell temperature jump experiments induce monomer collapse, misfolding and self-association of the Huntingtin exon 1 protein.

Funder

National Health and Medical Research Council

Deutsche Forschungsgemeinschaft

Australian Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2017/CP/C6CP08167C

Reference59 articles.

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3. Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice

4. Towards a transgenic model of Huntington’s disease in a non-human primate

5. Amyloid-like Features of Polyglutamine Aggregates and Their Assembly Kinetics

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