Switching a regular tryptophan C4-prenyltransferase to a reverse tryptophan-containing cyclic dipeptide C3-prenyltransferase by sequential site-directed mutagenesis-Reference-Cited by-同舟云学术

Switching a regular tryptophan C4-prenyltransferase to a reverse tryptophan-containing cyclic dipeptide C3-prenyltransferase by sequential site-directed mutagenesis

Published:2018 Issue:36 Volume:16 Page:6688-6694
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zheng Liujuan¹²³⁴,Mai Peter¹²³⁴,Fan Aili¹²³⁴,Li Shu-Ming¹²³⁴^ORCID

Affiliation:

1. Institut für Pharmazeutische Biologie und Biotechnologie

2. Philipps-Universität Marburg

3. 35037 Marburg

4. Germany

Abstract

The site-directed mutagenesis of FgaPT2 switches a regular C4-prenylation to a reverse C3-prenylation of tryptophan-containing cyclic dipeptides.

Funder

Deutsche Forschungsgemeinschaft

China Scholarship Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB01735B

Reference35 articles.

1. Versicoamides F–H, Prenylated Indole Alkaloids from Aspergillus tennesseensis

2. 2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products

3. Prenylated indole derivatives from fungi: structure diversity, biological activities, biosynthesis and chemoenzymatic synthesis

4. The tRNA-Dependent Biosynthesis of Modified Cyclic Dipeptides

5. The nonribosomal synthesis of diketopiperazines in tRNA-dependent cyclodipeptide synthase pathways

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