Isotope effect analyses provide evidence for an altered transition state for RNA 2′-O-transphosphorylation catalyzed by Zn2+-Reference-Cited by-同舟云学术

Isotope effect analyses provide evidence for an altered transition state for RNA 2′-O-transphosphorylation catalyzed by Zn2+

Published:2016 Issue:24 Volume:52 Page:4462-4465
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Zhang Shuming¹²³⁴,Gu Hong¹²³⁴,Chen Haoyuan⁵⁶⁷⁴,Strong Emily¹²³⁴,Ollie Edward W.¹²³⁴,Kellerman Daniel¹²³⁴,Liang Danni¹²³⁴,Miyagi Masaru⁸⁹³⁴,Anderson Vernon E.¹²³⁴,Piccirilli Joseph A.¹⁰¹¹¹²⁴,York Darrin M.⁵⁶⁷⁴,Harris Michael E.¹²³⁴

Affiliation:

1. Department of Biochemistry

2. Case Western Reserve University School of Medicine

3. Cleveland

4. USA

5. Center for Integrative Proteomics Research

6. BioMaPS Institute for Quantitative Biology and Department of Chemistry and Chemical Biology

7. Rutgers University Piscataway

8. Case Center for Proteomics and Bioinformatics

9. Case Western Reserve University

10. Department of Chemistry and Department of Biochemistry and Molecular Biology

11. The University of Chicago

12. Chicago

Abstract

Solvent D₂O and¹⁸O kinetic isotope effects on RNA 2′-O-transphosphorylation catalyzed by Zn²⁺demonstrate an altered transition state relative to specific base catalysis.

Funder

National Institute of Allergy and Infectious Diseases

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CC/C5CC10212J

Reference46 articles.

1. Biological Phosphoryl-Transfer Reactions: Understanding Mechanism and Catalysis

2. Why nature really chose phosphate

3. Binuclear Metallohydrolases

4. Nucleases: diversity of structure, function and mechanism

5. The chemical versatility of RNA

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