Unveiling the promising anticancer activity of palladium(<scp>ii</scp>)–aryl complexes bearing diphosphine ligands: a structure–activity relationship analysis-Reference-Cited by-同舟云学术

Unveiling the promising anticancer activity of palladium(ii)–aryl complexes bearing diphosphine ligands: a structure–activity relationship analysis

Published:2024 Issue:19 Volume:53 Page:8463-8477
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Tonon Giovanni¹^ORCID,Mauceri Matteo¹,Cavarzerani Enrico¹,Piccolo Rachele¹,Santo Claudio¹,Demitri Nicola²^ORCID,Orian Laura³^ORCID,Nogara Pablo A.⁴^ORCID,Rocha João Batista T.⁴^ORCID,Canzonieri Vincenzo⁵⁶^ORCID,Rizzolio Flavio¹⁵^ORCID,Visentin Fabiano¹^ORCID,Scattolin Thomas³^ORCID

Affiliation:

1. Dipartimento di Scienze Molecolari e Nanosistemi, Università Ca’ Foscari, Campus Scientifico Via Torino 155, 30174 Venezia-Mestre, Italy

2. Elettra – Sincrotrone Trieste, S.S. 14 Km 163.5 in Area Science Park, 34149 Basovizza, Trieste, Italy

3. Dipartimento di Scienze Chimiche, Università degli Studi di Padova, via Marzolo 1, 35131 Padova, Italy

4. Departamento de Bioquímica e Biologia Molecular, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil

5. Pathology Unit, Centro di Riferimento Oncologico di Aviano (C.R.O.) IRCCSvia Franco Gallini 2, 33081, Aviano, Italy

6. Department of Medical, Surgical and Health Sciences, Università degli Studi di Trieste, Strada di Fiume 447, Trieste, Italy

Abstract

Pd–aryl complexes bearing a wide range of disphosphine, aryl and halide ligands were synthesized. Their remarkable in vitro and ex vivo anticancer activity seems to involve DNA as the main biotarget and an intrinsic apoptotic cell death mechanism.

Funder

Associazione Italiana per la Ricerca sul Cancro

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/DT/D4DT00919C

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