Chromone–deferiprone hybrids as novel MAO-B inhibitors and iron chelators for the treatment of Alzheimer's disease-Reference-Cited by-同舟云学术

Chromone–deferiprone hybrids as novel MAO-B inhibitors and iron chelators for the treatment of Alzheimer's disease

Published:2024 Issue:30 Volume:22 Page:6189-6197
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zou Da-Jiang¹²,Liu Ren-Zheng¹,Lv Yang-Jing¹,Guo Jia-Nan¹,Fan Miao-Liang¹,Zhang Chang-Jun¹,Xie Yuan-Yuan¹³⁴^ORCID

Affiliation:

1. College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, PR China

2. School of Ethnic-Minority Medicine, Guizhou Minzu University, Guiyang 50025, China

3. Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceutical, Zhejiang University of Technology, Hangzhou, China

4. Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, Key Laboratory of Pharmaceutical Engineering of Zhejiang Province, Hangzhou, 310014, China

Abstract

A chromone–deferiprone compound 25c was created as a promising lead for AD therapy, which displayed hMAO-B inhibition (IC50 = 1.58 μM), iron-chelating (pFe3+ = 18.79), antioxidant, anti-ferroptosis, and improving the cognitive impairment abilities.

Funder

National Basic Research Program of China

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D4OB00919C

Reference25 articles.

1. Retrospective real-world pilot data on transcranial pulse stimulation in mild to severe Alzheimer's patients

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