A novel hydrophobic tag leads to the efficient degradation of programmed death-ligand 1-Reference-Cited by-同舟云学术

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A novel hydrophobic tag leads to the efficient degradation of programmed death-ligand 1

Published:2024 Issue: Volume: Page:
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Gao Jieke¹,Xie Yongli²,Zhang Jiantao¹,Chen Huirong¹,Zou Yan¹,Cen Shan²,Zhou Jinming¹^ORCID

Affiliation:

1. Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Department of Chemistry, Zhejiang Normal University, 688 Yingbin Road, Jinhua 321004, P. R. China

2. Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, China

Abstract

The interaction of PD-L1 and PD-1 transmits the inhibitory signal to reduce the proliferation of antigen-specific T-cells in lymph nodes.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00320A

Reference34 articles.

1. PD-1 Is Expressed by Tumor-Infiltrating Immune Cells and Is Associated with Poor Outcome for Patients with Renal Cell Carcinoma

2. Programmed death-1 upregulation is correlated with dysfunction of tumor-infiltrating CD8+ T lymphocytes in human non-small cell lung cancer

3. Inside PD-1/PD-L1,2 with their inhibitors

4. Immune checkpoint therapy—current perspectives and future directions

5. Regulation and Function of the PD-L1 Checkpoint

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