Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-β-hydroxylase-Reference-Cited by-同舟云学术

Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-β-hydroxylase

Published:2021 Issue:4 Volume:12 Page:1327-1342
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Brewitz Lennart¹²³⁴^ORCID,Nakashima Yu¹²³⁴,Schofield Christopher J.¹²³⁴^ORCID

Affiliation:

1. Chemistry Research Laboratory

2. University of Oxford

3. Oxford

4. UK

Abstract

Efficient synthesis of 2-oxoglutarate derivatives enables identification of inhibitors and novel cosubstrates of human aspartate/asparagine-β-hydroxylase as revealed by spectroscopic and crystallographic studies.

Funder

Japan Society for the Promotion of Science

Wellcome Trust

Cancer Research UK

Biotechnology and Biological Sciences Research Council

Deutsche Forschungsgemeinschaft

Daiichi Sankyo Foundation of Life Science

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D0SC04301J

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4. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

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