Exploring the synthesis of aminal guanidine-based molecules: synthesis of cernumidine and analogues, and survey of its anti-inflammatory activity-Reference-Cited by-同舟云学术

Exploring the synthesis of aminal guanidine-based molecules: synthesis of cernumidine and analogues, and survey of its anti-inflammatory activity

Published:2024 Issue:12 Volume:48 Page:5247-5257
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Rippel Rafael¹^ORCID,Leitão Flávia¹^ORCID,Georgieva Miglena K.¹^ORCID,Mamede Rafael¹,Gomes Clara S. B.¹^ORCID,Roma-Rodrigues Catarina²³^ORCID,Fernandes Alexandra R.²³^ORCID,Lourenço Ana¹,Ferreira Luísa M.¹^ORCID,Branco Paula S.¹^ORCID

Affiliation:

1. LAQV@REQUIMTE, Chemistry Department of Nova School of Science and Technology, Nova University of Lisbon, Campus de Caparica, 2829-516 Caparica, Portugal

2. Associate Laboratory i4HB – Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA University Lisbon, 2819-516 Caparica, Portugal

3. UCIBIO – Applied Molecular Biosciences Unit, Department of Life Sciences, NOVA School of Science and Technology, NOVA University Lisbon, 2819-516 Caparica, Portugal

Abstract

Enantioselective total synthesis and anti-inflammatory potential evaluation of the natural alkaloid cernumidine and derivatives containing an hybrid aminal core.

Funder

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/NJ/D3NJ05406C

Reference48 articles.

1. Cernumidine and isocernumidine, new type of cyclic guanidine alkaloids from Solanum cernuum

2. Hidden in Plants—A Review of the Anticancer Potential of the Solanaceae Family in In Vitro and In Vivo Studies

3. Gastroprotective activity of the hydroethanolic extract and isolated compounds from the leaves of Solanum cernuum Vell.

4. Antigenotoxic and Antioxidant Properties of Solanum cernuum and Its Alkaloid, Cernumidine

5. Chemosensitizing Effect of Cernumidine Extracted from Solanum cernuum on Bladder Cancer Cells in Vitro

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