Aggregation-induced emission photosensitizer microneedles for enhanced melanoma photodynamic therapy

Author:

Liang Ling123,Peng Tuokai14,Geng Xin Yao23,Zhu Wenping14,Liu Chaoyong15ORCID,Peng Hui-Qing146ORCID,Chen Bo Zhi23,Guo Xin Dong23ORCID

Affiliation:

1. Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China

2. State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, China

3. Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China

4. State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China

5. College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China

6. Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of Technology, Guangzhou 510640, China

Abstract

The AIE photosensitiser TPE-EPy@CB[7] was prepared by supramolecular self-assembly, which effectively enhanced the type-I ROS generation capacity. MNs facilitated precise drug delivery and enhanced light penetration into deeper layers of the tumor.

Funder

National Natural Science Foundation of China

Beijing University of Chemical Technology

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

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