Discovery of quinazoline-2,4(1H,3H)-dione derivatives as novel PARP-1/2 inhibitors: design, synthesis and their antitumor activity-Reference-Cited by-同舟云学术

Discovery of quinazoline-2,4(1H,3H)-dione derivatives as novel PARP-1/2 inhibitors: design, synthesis and their antitumor activity

Published:2018 Issue:17 Volume:16 Page:3189-3202
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zhou Jie¹²³⁴⁵,Ji Ming⁶²³⁴⁵,Yao Haiping¹²³⁴⁵,Cao Ran¹²³⁴⁵,Zhao Hailong¹²³⁴⁵,Wang Xiaoyu¹²³⁴⁵,Chen Xiaoguang⁶²³⁴⁵,Xu Bailing¹²³⁴⁵^ORCID

Affiliation:

1. Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation

2. Institute of Materia

3. Chinese Academy of Medical Science & Peking Union Medical College

4. Beijing

5. China

6. State Key Laboratory of Bioactive Substance and Functions of Natural Medicines

Abstract

Novel quinazoline-2,4(1H,3H)-dione derivatives bearing a 3-amino pyrrolidine motif were identified as potent PARP-1/2 inhibitors with distinct binding features.

Funder

National Natural Science Foundation of China

Chinese Academy of Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB00286J

Reference36 articles.

1. Genomic instability — an evolving hallmark of cancer

2. The PARP superfamily

3. Putting poly (ADP-ribose) polymerase and other DNA repair inhibitors into clinical practice

4. PARP inhibitors: Synthetic lethality in the clinic

5. The diverse roles and clinical relevance of PARPs in DNA damage repair: Current state of the art

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