Structural isomers of saligenin-based β2-agonists: synthesis and insight into the reaction mechanism

Author:

Knežević Anamarija12345ORCID,Novak Jurica678910,Bosak Anita111234,Vinković Marijana13234

Affiliation:

1. Division of Organic Chemistry and Biochemistry

2. Ruđer Bošković Institute

3. 10000 Zagreb

4. Croatia

5. Faculty of Science and Technology

6. Laboratory of Computational Modeling of Drugs

7. Higher Medical and Biological School

8. South Ural State University

9. Chelyabinsk 454080

10. Russia

11. Biochemistry and Organic Analytical Chemistry Unit

12. Institute for Medical Research and Occupational Health

13. NMR Center

Abstract

The unexpected emergence of β-aryl-β-aminoethanol isomers in the reaction between aromatic β-halohydrin and amines was analyzed by experimental and computational methods.

Funder

Hrvatska Zaklada za Znanost

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference54 articles.

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3. Catalytic Efficiency of Primary β-Amino Alcohols and Their Derivatives in Organocatalysis

4. Foye's principles of medicinal chemistry , ed. W. O. Foye , T. L. Lemke and D. A. Williams , Wolters Kluwer Health/Lippincott Williams & Wilkins , Philadelphia , 7th edn, 2013

5. Pharmacology and Therapeutics of Bronchodilators Revisited

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