A droplet microfluidic platform for efficient enzymatic chromatin digestion enables robust determination of nucleosome positioning-Reference-Cited by-同舟云学术

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A droplet microfluidic platform for efficient enzymatic chromatin digestion enables robust determination of nucleosome positioning

Published:2018 Issue:17 Volume:18 Page:2583-2592
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Xu Yi¹²³⁴¹^ORCID,Lee Jeong-Heon⁵⁶⁷⁸⁴^ORCID,Li Zhaoyu⁹⁷¹⁰⁴^ORCID,Wang Liguo¹¹⁷⁸⁴^ORCID,Ordog Tamas⁵⁶⁷⁸⁴^ORCID,Bailey Ryan C.¹²³⁴¹^ORCID

Affiliation:

1. Department of Chemistry

2. University of Michigan

3. Ann Arbor

4. USA

5. Epigenomics Program

6. Center for Individualized Medicine

7. Mayo Clinic

8. Rochester

9. Department of Cancer Biology

10. Jacksonville

11. Department of Health Sciences Research

Abstract

A microfluidic device was designed to efficiently fragment chromatin for downstream epigenetic assays.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2018/LC/C8LC00599K

Reference67 articles.

1. Crystal structure of the nucleosome core particle at 2.8 Å resolution

2. Nucleosome positioning and gene regulation: advances through genomics

3. Determinants of nucleosome positioning

4. Post-Translational Modifications of Histones That Influence Nucleosome Dynamics

5. Chromatin Higher-order Structure and Dynamics

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