Discovery of unexpectedly complex reaction pathways for the Knorr pyrazole synthesis <i>via</i> transient flow-Reference-Cited by-同舟云学术

Discovery of unexpectedly complex reaction pathways for the Knorr pyrazole synthesis via transient flow

Published:2023 Issue:1 Volume:8 Page:41-46
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Schrecker Linden¹^ORCID,Dickhaut Joachim²,Holtze Christian²,Staehle Philipp²,Vranceanu Marcel²,Hellgardt Klaus³,Hii King Kuok (Mimi)¹^ORCID

Affiliation:

1. Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, 82 Wood Lane, London W12 0BZ, UK

2. BASF SE, 38 Carl-Bosch-Straße, 67056, Ludwigshafen/Rhein, Germany

3. Department of Chemical Engineering, Imperial College London, South Kensington, London SW7 2AZ, UK

Abstract

Kinetic data for the Knorr pyrazole synthesis were acquired using transient flow methods, including a novel reactant stoichiometry ramping method, providing new insights into the mechanism, including autocatalysis and an unexpected intermediate.

Funder

BASF

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RE/D2RE00271J

Reference19 articles.

1. The Flow’s the Thing…︁Or Is It? Assessing the Merits of Homogeneous Reactions in Flask and Flow

2. Improved Method for Kinetic Studies in Microreactors Using Flow Manipulation and Noninvasive Raman Spectrometry

3. Thermolysis of 1,3-dioxin-4-ones: fast generation of kinetic data using in-line analysis under flow

4. Rapid multistep kinetic model generation from transient flow data

5. Automated generation of photochemical reaction data by transient flow experiments coupled with online HPLC analysis

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