Synthesis of novel phthalazine-based derivatives with potent cytotoxicity against HCT-116 cells through apoptosis and VEGFR2 inhibition-Reference-Cited by-同舟云学术

Synthesis of novel phthalazine-based derivatives with potent cytotoxicity against HCT-116 cells through apoptosis and VEGFR2 inhibition

Published:2024 Issue:19 Volume:14 Page:13027-13043
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

El Sayed Donia¹,El Rayes Samir M.¹^ORCID,Soliman Hamdy A.¹,AlBalaa Imad Eddin²^ORCID,Alturki Mansour S.³,Al Khzem Abdulaziz Hassan³,Alsharif Mohammed Abdullah⁴,Nafie Mohamed S.¹⁵^ORCID

Affiliation:

1. Chemistry Department, Faculty of Science, Suez Canal University, P.O. 41522, Ismailia, Egypt

2. Science Department, Faculty of Basic Educations, PAAET, Kuwait, Safat 22081, Kuwait

3. Department of Pharmaceutical Chemistry, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Eastern Province, Kingdom of Saudi Arabia

4. King Fahad Armed Forces Hospital, Al Kurnaysh Rd, Al Andalus, Jeddah 23311, Kingdom of Saudi Arabia

5. Department of Chemistry, College of Sciences, University of Sharjah, P.O. 27272, Sharjah, United Arab Emirates

Abstract

A novel phthalazine derivative exhibited potent cytotoxicity against HCT-116 cells as VEGFR2 inhibitor and apoptosis cell death.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA02103G

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