Synthesis of new piperazinyl-pyrrolo[1,2-a]quinoxaline derivatives as inhibitors of Candida albicans multidrug transporters by a Buchwald–Hartwig cross-coupling reaction-Reference-Cited by-同舟云学术

Synthesis of new piperazinyl-pyrrolo[1,2-a]quinoxaline derivatives as inhibitors of Candida albicans multidrug transporters by a Buchwald–Hartwig cross-coupling reaction

Published:2020 Issue:5 Volume:10 Page:2915-2931
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Guillon Jean¹²³⁴⁵,Nim Shweta⁶⁷⁸⁹,Moreau Stéphane¹²³⁴⁵,Ronga Luisa¹²³⁴⁵,Savrimoutou Solène¹²³⁴⁵,Thivet Elisabeth¹²³⁴⁵,Marchivie Mathieu¹⁰¹¹¹¹²¹³,Di Pietro Attilio¹⁴¹⁵¹⁶¹⁷¹⁸,Prasad Rajendra¹⁹²⁰²¹⁹,Le Borgne Marc²²²³²⁴²⁵²⁶^ORCID

Affiliation:

1. Univ. Bordeaux

2. INSERM U1212 – UMR CNRS 5320

3. ARNA Laboratory

4. UFR des Sciences Pharmaceutiques

5. F-33076 Bordeaux Cedex

6. School of Life Sciences

7. Jawaharlal Nehru University

8. 110067 New Delhi

9. India

10. CNRS

11. Bordeaux INP

12. ICMCB

13. UMR 5026

14. DRMP Group

15. IBCP

16. UMR 5086 (MMSB)

17. CNRS/Lyon I University

18. 69367 Lyon

19. Amity Institute of Integrative Sciences and Health

20. Amity University

21. Gurgaon 122413

22. Université de Lyon

23. Université Claude Bernard Lyon 1

24. Faculté de Pharmacie – ISPB

25. EA 4446 Bioactive Molecules and Medicinal Chemistry

26. SFR Santé Lyon-Est CNRS UMS3453 – INSERM US7

Abstract

Two series of piperazinyl-pyrrolo[1,2-a]quinoxaline derivatives were prepared via a Buchwald–Hartwig cross-coupling reaction and then evaluated for their ability to inhibit the drug efflux activity of two Candida albicans transporters.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RA/C9RA09348F

Reference52 articles.

1. Changing patterns and trends in systemic fungal infections

2. In Vitro Susceptibility of Invasive Isolates of Candida spp. to Anidulafungin, Caspofungin, and Micafungin: Six Years of Global Surveillance

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4. Clinical, Cellular, and Molecular Factors That Contribute to Antifungal Drug Resistance

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