Dimers formed with the mixed-type G-quadruplex binder pyridostatin specifically recognize human telomere G-quadruplex dimers-Reference-Cited by-同舟云学术

Dimers formed with the mixed-type G-quadruplex binder pyridostatin specifically recognize human telomere G-quadruplex dimers

Published:2020 Issue:5 Volume:18 Page:920-930
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Ma Tian-Zhu¹²³⁴⁵,Zhang Meng-Jia¹²³⁴⁵,Liao Ting-Cong¹²³⁴⁵,Li Jun-Hui¹²³⁴⁵,Zou Min¹²³⁴⁵,Wang Zhou-Mo⁶⁷⁸⁵,Zhou Chun-Qiong¹²³⁴⁵^ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of New Drug Screening

2. School of Pharmaceutical Sciences

3. Southern Medical University

4. Guangzhou 510515

5. P. R. China

6. Medical School

7. Science and Technology College of Hubei University for Nationalities

8. Enshi 445000

Abstract

By adjusting the length of the polyether linkers, pyridostatin (PDS) dimers displayed higher binding selectivities and thermal stabilization towards human telomere antiparallel and mixed-type G-quadruplex dimers (G2T1).

Funder

Guangdong Science and Technology Department

Southern Medical University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/C9OB02470K

Reference50 articles.

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5. The exception that confirms the rule: a higher-order telomeric G-quadruplex structure more stable in sodium than in potassium

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