Elucidation of fluorine's impact on pKa and in vitro Pgp-mediated efflux for a series of PDE9 inhibitors-Reference-Cited by-同舟云学术

Elucidation of fluorine's impact on pKa and in vitro Pgp-mediated efflux for a series of PDE9 inhibitors

Published:2018 Issue:5 Volume:9 Page:893-896
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Fjelbye Kasper¹²³⁴⁵^ORCID,Marigo Mauro¹²³^ORCID,Clausen Rasmus P.⁴⁵⁶⁷³^ORCID,Jørgensen Erling B.¹²³,Christoffersen Claus T.¹²³^ORCID,Juhl Karsten¹²³^ORCID

Affiliation:

1. H. Lundbeck A/S

2. 2500 Valby

3. Denmark

4. Department of Drug Design and Pharmacology

5. Faculty of Health and Medical Sciences

6. University of Copenhagen

7. Copenhagen

Abstract

The influence of replacing a hydrogen atom with fluorine on the pK_a and Pgp-mediated efflux is elucidated for a series of PDE9 inhibitors.

Funder

Uddannelses- og Forskningsministeriet

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/MD/C8MD00114F

Reference18 articles.

1. Improving Drug Candidates by Design: A Focus on Physicochemical Properties As a Means of Improving Compound Disposition and Safety

2. The role of ligand efficiency metrics in drug discovery

3. Improving the Odds of Success in Drug Discovery: Choosing the Best Compounds for in Vivo Toxicology Studies

4. Fluorine in Pharmaceuticals: Looking Beyond Intuition

5. ADMET rules of thumb II: A comparison of the effects of common substituents on a range of ADMET parameters

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