Molecular tweezers target a protein–protein interface and thereby modulate complex formation-Reference-Cited by-同舟云学术

Molecular tweezers target a protein–protein interface and thereby modulate complex formation

Published:2016 Issue:98 Volume:52 Page:14141-14144
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Trusch F.¹²³⁴⁵^ORCID,Kowski K.¹⁶⁴⁵,Bravo-Rodriguez K.⁷⁸⁹⁵,Beuck C.¹²³⁴⁵,Sowislok A.¹⁶⁴⁵,Wettig B.¹⁶⁴⁵,Matena A.¹²³⁴⁵,Sanchez-Garcia E.⁷⁸⁹⁵,Meyer H.¹¹⁰³⁴⁵,Schrader T.¹⁶⁴⁵,Bayer P.¹²³⁴⁵^ORCID

Affiliation:

1. University of Duisburg-Essen

2. Research Group Structural and Medicinal Biochemistry

3. Centre for Medical Biotechnology (ZMB)

4. 45117 Essen

5. Germany

6. Research Group Organic Chemistry

7. Max-Planck-Institut für Kohlenforschung

8. Kaiser-Wilhelm-Platz 1

9. 45470 Mülheim an der Ruhr

10. Research Group Molecular Biology I

Abstract

Supramolecular binders select few residues on a protein surface and by their unique complexation mode disrupt a critical protein–protein interaction.

Funder

Boehringer Ingelheim Stiftung

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CC/C6CC08039A

Reference17 articles.

1. Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality

2. Modulators of Protein–Protein Interactions

3. Protein recognition using synthetic small-molecular binders toward optical protein sensing in vitro and in live cells

4. Combining supramolecular chemistry with biology

5. Molecular Tweezer and Clip in Aqueous Solution: Unexpected Self-Assembly, Powerful Host−Guest Complex Formation, Quantum Chemical 1H NMR Shift Calculation

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