Synthesis, enzyme inhibition assay, and molecular modeling study of novel pyrazolines linked to 4-methylsulfonylphenyl scaffold: antitumor activity and cell cycle analysis-Reference-Cited by-同舟云学术

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Synthesis, enzyme inhibition assay, and molecular modeling study of novel pyrazolines linked to 4-methylsulfonylphenyl scaffold: antitumor activity and cell cycle analysis

Published:2024 Issue:31 Volume:14 Page:22132-22146
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Abdel-Aziz Alaa A.-M.¹^ORCID,El-Azab Adel S.¹^ORCID,Brogi Simone²^ORCID,Ayyad Rezk R.³^ORCID,Alkahtani Hamad M.¹^ORCID,Abuelizz Hatem A.¹^ORCID,Al-Suwaidan Ibrahim A.¹,Al-Obaid Abdulrahman M.¹

Affiliation:

1. Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh 11451, Saudi Arabia

2. Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy

3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-AzharUniversity, Cairo, Egypt

Abstract

Antitumor activity using 59 cancer cell lines and enzyme inhibitory activity of a newly synthesized pyrazoline-linked 4-methylsulfonylphenyl scaffold (compounds 18a–q) were measured and compared with those of standard drugs.

Funder

King Saud University

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA03902E

Reference82 articles.

1. C.Avendaño and J. C.Menendez , Medicinal Chemistry of Anticancer Drugs , Elsevier , 2015

2. Novel Anticancer Targets and Drug Discovery in Post Genomic Age

3. The New Era in Cancer Research

4. Cardiorespiratory fitness, physical activity and cancer mortality in men

5. The ever‐increasing importance of cancer as a leading cause of premature death worldwide

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