Ex vivo binding studies of the anti-cancer drug noscapine with human hemoglobin: a spectroscopic and molecular docking study

Author:

Chugh Heerak1234,Kumar Pramod15674ORCID,Kumar Neeraj1234ORCID,Gaur Rajesh K.8910,Dhawan Gagan111224ORCID,Chandra Ramesh1234ORCID

Affiliation:

1. Department of Chemistry

2. University of Delhi

3. Delhi 110007

4. India

5. Mahamana Malviya College Khekra (Baghpat)

6. C. C. S. University

7. Meerut

8. Division of Medical Oncology

9. University of Southern California

10. USA

11. Department of Biomedical Science

12. Acharya Narendra Dev College

Abstract

Noscapine binds human hemoglobin spontaneously forming a stable complex that affects noscapine's ADMET profile, bioavailability and toxicity.

Funder

Council of Scientific and Industrial Research

Science and Engineering Research Board

University Grants Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

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