A star shaped acoustofluidic mixer enhances rapid malaria diagnostics <i>via</i> cell lysis and whole blood homogenisation in 2 seconds-Reference-Cited by-同舟云学术

A star shaped acoustofluidic mixer enhances rapid malaria diagnostics via cell lysis and whole blood homogenisation in 2 seconds

Published:2022 Issue:9 Volume:22 Page:1829-1840
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Pourabed Amir¹^ORCID,Chakkumpulakkal Puthan Veettil Thulya²^ORCID,Devendran Citsabehsan¹^ORCID,Nair Prasanna¹³^ORCID,Wood Bayden R.²^ORCID,Alan Tuncay¹^ORCID

Affiliation:

1. Department of Mechanical and Aerospace Engineering, Monash University, Melbourne, VIC, Australia

2. Monash Centre for Biospectroscopy, Department of Chemistry, Monash University, Melbourne, VIC, Australia

3. Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, India

Abstract

Shear stresses generated by a silicon resonator embedded inside a microfluidic channel can rapidly and effectively lyse cells and homogenise whole blood. This significantly improves sensitivity of ATR-FTIR spectroscopy based diagnostic tests.

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/LC/D2LC00195K

Reference51 articles.

1. W. H. Organization , in World malaria report 2020: 20 years of global progress and challenges , 2020

2. Infrared Spectroscopy of Blood

3. Infrared spectroscopy coupled to cloud-based data management as a tool to diagnose malaria: a pilot study in a malaria-endemic country

4. Improved detection of Trypanosoma brucei by lysis of red blood cells, concentration and LED fluorescence microscopy

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