A novel mucoadhesive paliperidone-nanoemulsion developed using the ultrasonication method in the treatment of schizophrenia-Reference-Cited by-同舟云学术

A novel mucoadhesive paliperidone-nanoemulsion developed using the ultrasonication method in the treatment of schizophrenia

Published:2024 Issue:33 Volume:14 Page:23952-23972
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Ahmad Niyaz¹²^ORCID,Ansari Khalid³,Alamoudi Mariam K.⁴,Haque Anzarul⁵,Ullah Zabih⁶,Khalid Mohammed Saifuddin⁷,Ahmad Sarfaraz⁸

Affiliation:

1. Department of Pharmaceutics, College of Dentistry and Pharmacy, Buraydah Colleges, Buraydah, Alqassim, Saudi Arabia

2. Department of Pharmaceutical Sciences, Green Lab, Riyadh, Saudi Arabia

3. Liwa College, Faculty of Medical and Health Sciences, Abu Dhabi, United Arab Emirates

4. Department of Pharmacology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia

5. Central Laboratories Unit, Qatar University, Doha 2713, Qatar

6. Department of Pharmaceutical Sciences, College of Dentistry and Pharmacy, Buraydah Colleges, Alqassim, Saudi Arabia

7. Department of Pharmacology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia

8. Department of Clinical Pharmacy, College of Pharmacy, Jazan University, Jazan 114, Saudi Arabia

Abstract

Enhancing the brain bioavailability of paliperidone by developing a novel mucoadhesive-CS-coated-PLP-NE and examining the quantity of PLP by developing a novel method of ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) in schizophrenic rat brain treatment.

Funder

Deanship of Scientific Research, Prince Sattam bin Abdulaziz University

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA04624B

Reference47 articles.

1. A simple and rapid LC-MS/MS method for the simultaneous determination of eight antipsychotics in human serum, and its application to therapeutic drug monitoring

2. Unraveling enhanced brain delivery of paliperidone-loaded lipid nanoconstructs: pharmacokinetic, behavioral, biochemical, and histological aspects

3. Effects of first-generation antipsychotics versus second-generation antipsychotics on quality of life in schizophrenia: a double-blind, randomised study

4. Possible strategies to cross the blood–brain barrier

5. Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors