The inverting mechanism of the metal ion-independent LanGT2: the first step to understand the glycosylation of natural product antibiotic precursors through QM/MM simulations-Reference-Cited by-同舟云学术

The inverting mechanism of the metal ion-independent LanGT2: the first step to understand the glycosylation of natural product antibiotic precursors through QM/MM simulations

Published:2021 Issue:26 Volume:19 Page:5888-5898
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Mendoza Fernanda¹²³⁴⁵^ORCID,Jaña Gonzalo A.¹²³⁴⁵^ORCID

Affiliation:

1. Departamento de Ciencias Químicas

2. Facultad de Ciencias Exactas

3. Universidad Andres Bello

4. Talcahuano

5. Chile

Abstract

Glycosyltransferases (GTs) from the GT1 family are responsible for the glycosylation of various important organic structures such as terpenes, steroids and peptide antibiotics, making it one of the most intensely studied families of GTs.

Funder

Fondo Nacional de Desarrollo Científico y Tecnológico

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB00544H

Reference64 articles.

1. Glycosyltransferases: mechanisms and applications in natural product development

2. The impact of enzyme engineering upon natural product glycodiversification

3. Sweet antibiotics – the role of glycosidic residues in antibiotic and antitumor activity and their randomization