Issue 26, 2024

Growth “self-inhibition” of irbesartan desmotrope: surface intra-annular tautomer inter-conversion is the culprit

Abstract

The newly discovered growth self-inhibition phenomenon of tautomeric crystals is now generalized to the demostrope (form B) of irbesartan that displays intra-annular tautomerism in neutral aqueous solutions. The dynamic intra-annular tautomer inter-conversion on the surface is the key factor. Our findings provide implications for producing and engineering tautomeric materials.

Graphical abstract: Growth “self-inhibition” of irbesartan desmotrope: surface intra-annular tautomer inter-conversion is the culprit

Supplementary files

Article information

Article type
Communication
Submitted
19 Dec 2023
Accepted
19 Feb 2024
First published
27 Feb 2024

Chem. Commun., 2024,60, 3511-3514

Growth “self-inhibition” of irbesartan desmotrope: surface intra-annular tautomer inter-conversion is the culprit

X. Kang, M. Zhang, W. Tang and J. Gong, Chem. Commun., 2024, 60, 3511 DOI: 10.1039/D3CC06170A

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