Colon-targeted oral nanoliposomes loaded with psoralen alleviate DSS-induced ulcerative colitis

Author:

Su Liqian1ORCID,Song Gaoqing123,Zhou Tao123,Tian Hongmei123,Xin Hui123,Zou Xuan2,Xu Yinghua4,Jin Xiaobao1,Gui Shuiqing3,Lu Xuemei12ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, School of BasicMedical Sciences, Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China

2. Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, People's Republic of China

3. Intensive Care Unit, Shenzhen Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen 518031, People's Republic of China

4. Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotechnology Products, National Institutes for Food and Drug Control, Beijing 102629, People's Republic of China

Abstract

Psoralen-loaded nanoliposomes have pH and microbiota-sensitive characteristics, which can target the colon after oral administration to play an anti-ulcerative colitis role.

Funder

National Natural Science Foundation of China

Sanming Project of Medicine in Shenzen Municipality

Basic and Applied Basic Research Foundation of Guangdong Province

Publisher

Royal Society of Chemistry (RSC)

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