Orthogonal, dual protein labelling by tandem cycloaddition of strained alkenes and alkynes to ortho-quinones and azides-Reference-Cited by-同舟云学术

Orthogonal, dual protein labelling by tandem cycloaddition of strained alkenes and alkynes to ortho-quinones and azides

Published:2018 Issue:53 Volume:54 Page:7338-7341
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Bruins Jorick J.¹²³⁴^ORCID,Blanco-Ania Daniel⁵⁶⁷⁴^ORCID,van der Doef Vincent¹²³⁴,van Delft Floris L.¹²³⁴^ORCID,Albada Bauke¹²³⁴^ORCID

Affiliation:

1. Laboratory of Organic Chemistry

2. Wageningen University & Research

3. Wageningen

4. the Netherlands

5. Institute for Molecules and Materials

6. Radboud University

7. Nijmegen

Abstract

Novel click chemistry using SPAAC and SPOCQ in tandem efficiently provides dual-labelled antibody–drug–dye conjugates.

Funder

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CC/C8CC02638F

Reference34 articles.

1. Click Chemistry and Bioorthogonal Reactions: Unprecedented Selectivity in the Labeling of Biological Molecules

2. Bioorthogonal chemistry: recent progress and future directions

3. Bioorthogonal Cycloadditions: Computational Analysis with the Distortion/Interaction Model and Predictions of Reactivities

4. Metal-free bioconjugation reactions

5. Cell Surface Engineering by a Modified Staudinger Reaction

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