<i>Senegalia macrostachya</i> seed polysaccharides attenuate inflammation-induced intestinal epithelial barrier dysfunction in a Caco-2 and RAW264.7 macrophage co-culture model by inhibiting the NF-κB/MLCK pathway-Reference-Cited by-同舟云学术

Senegalia macrostachya seed polysaccharides attenuate inflammation-induced intestinal epithelial barrier dysfunction in a Caco-2 and RAW264.7 macrophage co-culture model by inhibiting the NF-κB/MLCK pathway

Published:2022 Issue:22 Volume:13 Page:11676-11689
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Zongo Abel Wend-Soo¹²³^ORCID,Zogona Daniel¹²³^ORCID,Youssef Mahmoud⁴^ORCID,Ye Shuxin¹²,Zhan Fuchao¹²,Li Jing¹²,Li Bin¹²^ORCID

Affiliation:

1. College of Food Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China

2. Key Laboratory of Environment Correlative Dietology (Huazhong Agricultural University), Ministry of Education, China

3. Center for Research in Biological Sciences, Food and Nutrition, Department of Biochemistry and Microbiology, University Joseph Ki-Zerbo, BP 7021 Ouagadougou 03, Burkina Faso

4. Food Science and Technology Department, Faculty of Agriculture, Al-Azhar University, Cairo, Egypt

Abstract

Senegalia macrostachya seed polysaccharides improved the Caco-2 cell monolayer integrity from the inflammatory insult. SMSP2 treatment lowered the inflammatory cytokine release, increased TJ proteins, and downregulated the NF-κB/MLCK pathway.

Funder

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/FO/D2FO02377F

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4. Longan pulp polysaccharides relieve intestinal injury in vivo and in vitro by promoting tight junction expression

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