Application of bioorthogonal hetero-Diels–Alder cycloaddition of 5-arylidene derivatives of 1,3-dimethylbarbituric acid and vinyl thioether for imaging inside living cells

Author:

Bazan Bartłomiej12345ORCID,Pałasz Aleksandra12345ORCID,Skalniak Łukasz12345ORCID,Cież Dariusz12345ORCID,Buda Szymon12345ORCID,Jędrzejowska Katarzyna12345ORCID,Głomb Sonia12345,Kamzol Daniel12345,Czarnota Kinga12345,Latos Krystian12345,Kozieł Krzysztof12345ORCID,Musielak Bogdan12345ORCID

Affiliation:

1. Department of Organic Chemistry

2. Faculty of Chemistry

3. Jagiellonian University

4. 30-387 Kraków

5. Poland

Abstract

The fluorescent 5-arylidene derivative of 1,3-dimethylbarbituric acid as a heterodiene reacted with vinyl thioether equipped with a taxol. The cycloadditions rate constants k2 were estimated to be in the range from 0.9 × 10−2 M−1 s−1 to 1.4 M−1 s−1.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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