Copper/ruthenium relay catalysis enables 1,6-double chiral inductions with stereodivergence-Reference-Cited by-同舟云学术

Copper/ruthenium relay catalysis enables 1,6-double chiral inductions with stereodivergence

Published:2024 Issue:26 Volume:15 Page:10135-10145
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Yang Hao-Ran¹,Cheng Xiang¹,Chang Xin¹,Wang Zuo-Fei¹,Dong Xiu-Qin¹^ORCID,Wang Chun-Jiang¹²^ORCID

Affiliation:

1. College of Chemistry and Molecular Sciences, Engineering Research Center of Organosilicon Compounds & Materials, Ministry of Education, Wuhan University, Wuhan, Hubei, 430072, P. R. China

2. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Shanghai 230021, China

Abstract

A stereodivergent synthesis of chiral ζ-hydroxy amino esters containing 1,6-stereocenters and a unique β,γ-unsaturation was developed through asymmetric Cu/Ru relay catalysis to conduct the borrowing hydrogenation/1,6-Michael addition protocol.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Natural Science Foundation of Hubei Province

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC01804D

Reference93 articles.

1. Drug Discovery and Natural Products: End of an Era or an Endless Frontier?

2. Natural Products as Sources of New Drugs over the Last 25 Years

3. Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

4. K.Jozwiak , W. J.Lough and I. W.Wainer , Drug Stereochemistry: Analytical Methods and Pharmacology , CRC Press , Boca Raton , 3rd edn, 2012

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A Highly Atom-Economic Stereodivergent Synthesis of Remote 1,6-Aminoalcohols;Synfacts;2024-07-25