Photoactive PtII and PdII complexes of N,N-diethyl-N′-3,4,5-trimethoxybenzoylthiourea: synthesis, crystal structures, DFT and cytotoxicity studies-Reference-Cited by-同舟云学术

Photoactive PtII and PdII complexes of N,N-diethyl-N′-3,4,5-trimethoxybenzoylthiourea: synthesis, crystal structures, DFT and cytotoxicity studies

Published:2021 Issue:32 Volume:45 Page:14703-14712
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Nkabyo H. A.¹²³^ORCID,Oyenihi O. R.⁴⁵⁶³,Olaoye O.⁷⁸²³,Sikiti P.¹²³,Bosman G. W.⁷⁸²³,Luckay R. C.¹²³

Affiliation:

1. Department of Chemistry and Polymer Science

2. Stellenbosch University

3. South Africa

4. Department of Pharmacology

5. University of the Free State

6. Bloemfontein 9300

7. Laser Research Institute

8. Department of Physics

Abstract

New trans-Pd^II/Pt^II acylthiourea complexes prepared by photo-induced isomerism are found to be more cytotoxic than cis-Pd^II/Pt^II against human prostate cancer and normal embryonic kidney cell lines.

Funder

Universiteit Stellenbosch

National Research Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NJ/D1NJ02320A

Reference44 articles.

1. Structure-dependent in vitro cytotoxicity of the isomeric complexes [Ru(L)2Cl2] (L=o-tolylazopyridine and 4-methyl-2-phenylazopyridine) in comparison to [Ru(azpy)2Cl2]

2. Synthesis, Characterization, and Cytotoxicity of Trifunctional Dinuclear Platinum Complexes: Comparison of Effects of Geometry and Polyfunctionality on Biological Activity

3. Photocytotoxic trans-Diam(m)ine Platinum(IV) Diazido Complexes More Potent than Their cis Isomers

4. A Photoactivatedtrans-Diammine Platinum Complex as Cytotoxic as Cisplatin

5. Elucidation of Binding Site and Chiral Specificity of Oxidovanadium Drugs with Lysozyme through Theoretical Calculations

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