Microphysiological pancreas-on-chip platform with integrated sensors to model endocrine function and metabolism

Author:

Schlünder Katharina12ORCID,Cipriano Madalena1ORCID,Zbinden Aline3,Fuchs Stefanie4,Mayr Torsten4ORCID,Schenke-Layland Katja23ORCID,Loskill Peter125ORCID

Affiliation:

1. Department for Microphysiological Systems, Institute of Biomedical Engineering, Eberhard Karls University Tübingen, Tübingen, Germany

2. NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany

3. Department for Medical Technologies and Regenerative Medicine, Institute of Biomedical Engineering, Eberhard Karls University Tübingen, Tübingen, Germany

4. Institute for Analytical Chemistry and Food Chemistry, Graz University of Technology, Graz, Austria

5. 3R-Center for In vitro Models and Alternatives to Animal Testing, Eberhard Karls University Tübingen, Tübingen, Germany

Abstract

Pancreatic in vitro models are crucial for research on diseases such as diabetes mellitus. A novel thermoplastic organ-on-chip with integrated real-time read-outs models the complex microphysiological structure and function of the endocrine pancreas.

Funder

Horizon 2020

Publisher

Royal Society of Chemistry (RSC)

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