Live cell screening to identify RNA-binding small molecule inhibitors of the pre-let-7–Lin28 RNA–protein interaction-Reference-Cited by-同舟云学术

Live cell screening to identify RNA-binding small molecule inhibitors of the pre-let-7–Lin28 RNA–protein interaction

Published:2024 Issue:5 Volume:15 Page:1539-1546
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Rosenblum Sydney L.¹^ORCID,Soueid Dalia M.²,Giambasu George³^ORCID,Vander Roest Steve⁴,Pasternak Alexander⁵,DiMauro Erin F.⁵,Simov Vladimir⁵^ORCID,Garner Amanda L.¹²^ORCID

Affiliation:

1. Program in Chemical Biology, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI, 48109, USA

2. Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, 1600 Huron Parkway, NCRC B520, Ann Arbor, MI 48109, USA

3. Computational Chemistry, Merck & Co., Inc., Boston, MA 02115, USA

4. Center for Chemical Genomics, Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI, 48109, USA

5. Discovery Chemistry, Merck & Co., Inc., Boston, MA 02115, USA

Abstract

Dysregulation of the networking of RNA-binding proteins (RBPs) and RNAs drives many human diseases, including cancers, and the targeting of RNA–protein interactions (RPIs) has emerged as an exciting area of RNA-targeted drug discovery.

Funder

Merck Sharp and Dohme Italia

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00123K

Reference71 articles.

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