Enhanced anticancer effect of lysozyme-functionalized metformin-loaded shellac nanoparticles on a 3D cell model: role of the nanoparticle and payload concentrations

Author:

Wang Anheng12ORCID,Madden Leigh A.3ORCID,Paunov Vesselin N.4ORCID

Affiliation:

1. Institute of Chinese Medical Sciences & State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macau SAR, China

2. Zhuhai UM Science and Technology Research Institute, University of Macau, Hengqin, Guangdong, China

3. Centre for Biomedicine, Hull York Medical School, University of Hull, HU67RX, UK

4. Department of Chemistry, Nazarbayev University, 53 Kabanbay Batyr Avenue, Astana, 010000, Kazakhstan

Abstract

We report a novel approach for effective targeting of 3D tumour cell culture based on protease-functionalised metformin nanocarriers and explore the roles of the nanoparticle concentration and the drug payload.

Funder

Ministry of Education and Science of the Republic of Kazakhstan

China Sponsorship Council

Publisher

Royal Society of Chemistry (RSC)

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