RiPP enzyme heterocomplex structure-guided discovery of a bacterial borosin α-<i>N</i>-methylated peptide natural product-Reference-Cited by-同舟云学术

RiPP enzyme heterocomplex structure-guided discovery of a bacterial borosin α-N-methylated peptide natural product

Published:2023 Issue:10 Volume:4 Page:804-816
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Crone K. K.¹^ORCID,Jomori T.²,Miller F. S.¹^ORCID,Gralnick J. A.²³,Elias M. H.¹²,Freeman M. F.¹²^ORCID

Affiliation:

1. Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota – Twin Cities, St. Paul 55108, USA

2. The BioTechnology Institute, University of Minnesota – Twin Cities, St. Paul 55108, USA

3. Department of Plant and Microbial Biology, University of Minnesota – Twin Cities, St. Paul 55108, USA

Abstract

Through a combination of in vitro structure–activity assays, crystallography, and in vivo knockout experiments, we have identified and structurally characterized the first bacterial borosin natural product.

Funder

National Institute of General Medical Sciences

Advanced Photon Sciences

Graduate School, University of Minnesota

Daiichi Sankyo Foundation of Life Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CB/D3CB00093A

Reference37 articles.

1. New developments in RiPP discovery, enzymology and engineering

2. N-Methylation of Peptides: A New Perspective in Medicinal Chemistry

3. Autocatalytic backbone N-methylation in a family of ribosomal peptide natural products

4. A Self‐Sacrificing N ‐Methyltransferase Is the Precursor of the Fungal Natural Product Omphalotin

5. Distinct Autocatalytic α-N-Methylating Precursors Expand the Borosin RiPP Family of Peptide Natural Products

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