Enantioselective construction of dihydropyranone-fused indoles by [3 + 3] annulation of in situ-derived indolin-3-ones and unsaturated carboxylic esters

Author:

Wang Hongling1,Zhang Qiangqiang1,Xiao Shuai1,Wang Guanjie1,Huang Xuan1,Chen Xingkuan2ORCID,Zhang Junmin1ORCID

Affiliation:

1. International Joint Research Center for Molecular Science, College of Chemistry and Environmental Engineering & College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, P. R. China

2. Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Department of Chemistry, Jinan University, Guangzhou, Guangdong 510632, P. R. China

Abstract

This work discloses an N-heterocyclic carbene (NHC) and base-mediated [3 + 3] annulation reaction of unsaturated carboxylic esters and sulfonium salts for rapid and direct access to enantioselective dihydropyrano[3,2-b]indoles.

Funder

Guangdong Provincial Key Laboratory Of Catalysis

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

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