Mechanistic studies of the reactions of the reduced vitamin B12 derivatives with the HNO donor Piloty's acid: further evidence for oxidation of cob(i)alamin by (H)NO-Reference-Cited by-同舟云学术

Mechanistic studies of the reactions of the reduced vitamin B12 derivatives with the HNO donor Piloty's acid: further evidence for oxidation of cob(i)alamin by (H)NO

Published:2016 Issue:1 Volume:45 Page:352-360
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Subedi Harishchandra¹²³⁴⁵,Brasch Nicola E.⁶⁷⁸⁹

Affiliation:

1. Department of Chemistry and Biochemistry

2. Kent State University

3. Kent

4. USA

5. Division of Science

6. School of Applied Sciences

7. Auckland University of Technology

8. Auckland 1142

9. New Zealand

Abstract

Kinetic data and product analyses support a mechanism in which cob(II)alamin (Cbl(ii)˙) is reduced by (H)NO to give cob(i)alamin (Cbl(i)⁻) and ˙NO. Cbl(i)⁻ is subsequently oxidized back to Cbl(ii)˙ by a second (H)NO molecule, and Cbl(ii)˙ reacts rapidly with ˙NO to form nitroxylcobalamin, NOCbl.

Funder

Division of Chemistry

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/DT/C5DT03459K

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