Enhancing cellular morphological changes and ablation of cancer cells via the interaction of drug co-loaded magnetic nanosystems in weak rotating magnetic fields

Author:

Wu Tingting12345ORCID,Zhang Qian678910,Hu Huiping111213514,Yang Fang1516171819,Li Ke12345,Zhang Yu12345,Shi Chen12345

Affiliation:

1. Department of Pharmacy

2. Union Hospital

3. Tongji Medical College

4. Huazhong University of Science & Technology (HUST)

5. Wuhan

6. Key Laboratory for Thin Film and Microfabrication Technology of the Ministry of Education

7. Department of Instrument Science and Engineering

8. School of Electronic Information and Electrical Engineering

9. Institute of Nano Biomedicine and Engineering

10. Shanghai Jiao Tong University

11. Hubei Key Laboratory of Nature Medicinal Chemistry and Resource Evaluation

12. Tongji Medical College of Huazhong

13. University of Science and Technology

14. China

15. Cixi Institute of Biomedical Engineering

16. CAS Key Laboratory of Magnetic Materials and Devices

17. Key Laboratory of Additive Manufacturing Materials of Zhejiang Province

18. Ningbo Institute of Materials Technology and Engineering

19. Chinese Academy of Sciences

Abstract

Tetrandrine and Fe3O4 nanoparticle co-loaded PLGA nanosystems produce rotational movement and promote tetrandrine release, causing a dual apoptotic effect to tumors.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Hubei Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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