Click-based injectable bioactive PEG-hydrogels guide rapid craniomaxillofacial bone regeneration by the spatiotemporal delivery of rhBMP-2-Reference-Cited by-同舟云学术

Click-based injectable bioactive PEG-hydrogels guide rapid craniomaxillofacial bone regeneration by the spatiotemporal delivery of rhBMP-2

Published:2023 Issue:14 Volume:11 Page:3136-3150
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Lao Weiwei¹^ORCID,Fan Lijie¹,Zhang Qiao¹,Lou Chaoqian¹,Li Hang¹,Li Yanyan¹,Wu Shuang¹,Li Xiaojun¹,Luo Qiaojie¹,Zhu Weipu²³^ORCID,Li Xiaodong¹^ORCID

Affiliation:

1. Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou 310000, China

2. MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China

3. Key Laboratory of Adsorption and Separation Materials & Technologies of Zhejiang Province, Hangzhou 310027, China

Abstract

A novel click-based bioactive injectable hydrogel based on two PEG derivatives realizes the efficient loading of rBMSCs and spatiotemporal delivery of rhBMP-2, basically accomplishing repair and regeneration of a critical-size defect within 4 weeks.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Science and Technology Department of Zhejiang Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2023/TB/D2TB02703H

Reference53 articles.

1. Craniomaxillofacial Disorders and Solutions in Humans and Animals