Computational investigation of curcumin, a natural polyphenol that inhibits the destabilization and the aggregation of human SOD1 mutant (Ala4Val)
Author:
Affiliation:
1. Computational Biology Lab
2. Department of Biotechnology
3. School of Bio Sciences and Technology
4. VIT University
5. Vellore 632014
Abstract
Curcumin inhibits the aberrant aggregation in mutant SOD1 protein, thereby decreasing the propensity of β-sheets and the toxicity level.
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA21927F
Reference47 articles.
1. Roles of zinc and copper in modulating the oxidative refolding of bovine copper, zinc superoxide dismutase
2. Protein misfolding and aggregation: new examples in medicine and biology of the dark side of the protein world
3. Misfolded CuZnSOD and amyotrophic lateral sclerosis
4. Cu/Zn superoxide dismutase gene mutations in amyotrophic lateral sclerosis: correlation between genotype and clinical features.
5. Structural investigation on the electrostatic loop of native and mutated SOD1 and their interaction with therapeutic compounds
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