Expanding medicinal chemistry into 3D space: metallofragments as 3D scaffolds for fragment-based drug discovery-Reference-Cited by-同舟云学术

Expanding medicinal chemistry into 3D space: metallofragments as 3D scaffolds for fragment-based drug discovery

Published:2020 Issue:5 Volume:11 Page:1216-1225
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Morrison Christine N.¹²³⁴^ORCID,Prosser Kathleen E.¹²³⁴,Stokes Ryjul W.¹²³⁴^ORCID,Cordes Anna⁵⁶⁷⁸⁹,Metzler-Nolte Nils⁵⁶⁷⁸⁹^ORCID,Cohen Seth M.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry

2. University of California San Diego

3. La Jolla

4. USA

5. Lehrstuhl für Anorganische Chemie 1

6. Bioanorganische Chemie

7. Ruhr-Universität Bochum

8. 44801 Bochum

9. Germany

Abstract

Fragment-based drug discovery (FBDD) using 3-dimensional metallofragments is a new strategy for the identification of bioactive molecules.

Funder

National Institute of General Medical Sciences

National Institute of Allergy and Infectious Diseases

Natural Sciences and Engineering Research Council of Canada

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/C9SC05586J

Reference62 articles.

1. Fragment-based lead discovery: leads by design

2. Recent Developments in Fragment-Based Drug Discovery

3. Fragment-Based Approaches in Drug Discovery and Chemical Biology

4. A ‘Rule of Three’ for fragment-based lead discovery?

5. Drugging challenging targets using fragment-based approaches

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