A modular approach to the bisbenzylisoquinoline alkaloids tetrandrine and isotetrandrine

Author:

Schütz Ramona1234ORCID,Meixner Maximilian5674,Antes Iris5674,Bracher Franz1234ORCID

Affiliation:

1. Department of Pharmacy – Center for Drug Research

2. Ludwig-Maximilians University Munich

3. 81377 Munich

4. Germany

5. TUM School of Life Sciences

6. Technical University Munich

7. 85354 Freising

Abstract

A modular short-step synthesis of the bisbenzylisoquinoline alkaloids tetrandrine and isotetrandrine was developed employingN-acyl-Pictet–Spengler reaction and Ullman diaryl ether synthesis as central steps.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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